Welcome to your slice of Old Florida paradise in the heart of Panacea! This charming canal front coastal retreat is nestled on a quiet street right off the Gulf, offering a laid-back environment on a beautiful 0.47 acre lot. The interior boasts exposed brick that has been renovated and is move in ready. Outside, enjoy your morning coffee or evening cocktails on the spacious deck with water views shaded by a large mature oak tree. The 3/2 has generous outdoor space for boat parking, cookouts, or future expansion. Just a short golf cart ride from local marinas, boat ramps, Angelos. This home is ideal for fishermen, beach lovers, and anyone chasing the coastal dream. You have no HOA and can use this as a short term rental. Come see why life is better in Panacea—schedule your private showing today!
Welcome to this beautifully remodeled 2-bedroom, 2-bath cottage-style home in the heart of Panacea, FL — a true gem for vacation rental potential or a fisherman’s getaway. Perfectly positioned near Dickerson and Levy Bay, this home offers quick access to some of North Florida’s best fishing waters. You’ll love being within walking distance to local restaurants, Rock Landing Marina, and all the charm of Panacea’s golf cart–friendly community. Inside, you’ll enjoy peace of mind with a wonderfully remodeled interior featuring modern updates and coastal character, while outside you’ll find a 50-amp breaker for your camper, public water and sewer, and the security of a recently updated roof. Whether you’re looking for an Airbnb investment, a weekend retreat, or your own coastal escape, this cottage delivers convenience, lifestyle, and income potential in one of the Forgotten Coast’s most welcoming communities.
Beautifully renovated bayfront home with direct Gulf access and stunning waterfront views! This elevated 3BR/2BA retreat was extensively updated in 2023 and features custom kitchen cabinetry, granite and quartz countertops, all-new appliances, new LVP flooring and lighting, a ventless gas fireplace, and Rinnai tankless water heater. The spacious primary suite offers a large walk-in closet and spa-style ensuite with a wet-room Jacuzzi soaking tub, dual shower heads, and body sprays. A wall of patio doors fills the home with natural light and peaceful water views. Designed for the ultimate Florida waterfront lifestyle, the property includes a deep-water dock with Sure-Step decking, covered boat lift, two jet ski lifts, electric, water, and fish-cleaning station, all added in 2021, plus a new seawall with stairs to the beach in 2023. Additional upgrades include a new roof, windows, and patio doors in 2021, RV hookup, buried propane tank with generator-ready hookup, irrigated manicured backyard, privacy fencing with automatic gated entry, and abundant parking with five spacious bays under the home. One of the rare Surf Rd properties where you can enjoy both sunrises and sunsets over the water. Boat, jet skis, and furniture negotiable. Move-in ready coastal living at its finest—enjoy boating, fishing, entertaining, and relaxing waterfront living right from your backyard. The biking/walking path along Surf Rd stretches for miles in either direction, and this golf-cart-friendly community makes it easy to ride to nearby shops, restaurants, and Mashes Sands Beach. Shed combo is 4321.
Enjoy breathtaking sunrises and panoramic views of Ochlockonee Bay and the Gulf of Mexico from this beautifully maintained 3-bedroom, 2.5 bath waterfront townhouse with a private boat slip and lift in the gated community of George's Lighthouse Pointe Marina Village. Designed for coastal living, the open floor plan features heart pine floors, abundant natural light, and spacious waterfront decks perfect for relaxing or entertaining. Boaters will love the quick access to world-class fishing, scalloping, and boating, with Mashes Sands Boat Ramp less than a half mile away. Community amenities include a pool and tennis courts. Conveniently located near Angelo's Seafood Restaurant, Mashes Sands Beach, Alligator Point, Bald Point State Park, Shell Point, and St. Marks, this home is ideal as a full-time residence, weekend getaway, or investment opportunity. Experience the relaxed lifestyle and unforgettable waterfront views that make Florida's Forgotten Coast so special.
Welcome to Marina Village! This beautifully updated 1,332 sq ft end unit townhouse offers 2 bedrooms and 2.5 baths, along with a flexible bonus space which could be used for an office, workout room, second living room, or another bedroom. Comes with a deeded boat slip (slip 19) complete with power and water. Enjoy bay views and refreshing sea breezes from the screened porches and mezzanine decks perfect for grilling and entertaining. The home features recent updates and an extended patio underneath, providing additional outdoor living space ideal for relaxing after a day on the water. Residents enjoy access to the newly built community pool, offering the perfect spot to unwind after fishing or spending time at the beach. Conveniently located just down the street from Mashes Sands Public Beach and boat ramp, the property also adjoins the scenic 16-mile Ochlockonee Bay bike and walking trail that winds along the water and through the St. Marks National Wildlife Refuge. With saltwater access, a boat slip, community pool, and low maintenance living, this property offers the ideal coastal retreat for full time living or weekend getaways.
Escape to this beauty of Florida's Forgotten Coast with this charming 2 bedroom, 1 bath condo nestled in the heart of Ochlockonee Bay! Whether you're searching for a weekend getaway, vacation rental, or low maintenance coastal retreat, this condo is packed with upgrades and an unbeatable location! This condo has many upgrades including LVP flooring, beautiful kitchen backsplash, renovated kitchen cabinets, brand new garbage disposal, newer black refrigerator, stove and microwave. Dishwasher in great working condition. Renovated walk in tile shower and stackable washer and dryer hookups added in the bathroom. Additional conveniences include an on site laundry facility with two large washer and dryers. Located just minutes from Mashes Sands and Alligator Point beaches, Angelo's seafood restaurant, boat ramps, fishing, new bike trail and everything that makes the Forgotten Coast so special. Relax by the community pool or play tennis! This one is a MUST SEE!
Wake up to breathtaking sunrises and panoramic views of Ochlockonee Bay as it opens into the Gulf of Mexico from this exceptional 4-bedroom, 2.5-bath waterfront townhouse with boat slip/boat lift in the highly sought-after gated community of George's Lighthouse Pointe Marina Village. Designed to embrace the coastal lifestyle, this spacious home features an open-concept floor plan with beautiful heart pine floors, abundant natural light, and multiple waterfront decks that provide the perfect setting for morning coffee, evening cocktails, or simply enjoying the ever-changing views of the bay. Boaters will appreciate the private boat slip and lift, offering quick access to some of North Florida's best fishing, scalloping, boating, and waterfront destinations such as the Shoals, Dog Island, St George State Park and so much more. The Mashes Sands Boat lift is less than 1/2 mile away. And you will certainly enjoy the community pool and tennis courts. Ideally located in the heart of the Forgotten Coast this home is Walking distance to the renowned Angelo's Seafood Restaurant, a short golf cart ride to Mashes Sands Beach. Minutes from the Mashes Sands Boat Ramp, making days on the water effortless. Easy access to Alligator Point, Bald Point State Park, Shell Point Beach, St. Marks, St George Island and some of Florida's most pristine Gulf waters Whether you're searching for a full-time waterfront residence, weekend getaway, or investment opportunity, this home offers the perfect blend of comfort, convenience, and unforgettable coastal scenery. Experience spectacular bay views, incredible sunsets, and the relaxed charm that make Panacea and Florida's Forgotten Coast the best kept secret.
This home is a perfect mix of convenience and coastal charm. The marina is just two blocks making it easy access for your boat. A variety of seafood and family restaurants only five minutes away. Over a half-acre yard with potential to add on a shed or pole barn for boat storage. Screened in porch and many decks for outdoor living. Metal roof. Quiet community near the Gulf Specimen Marine Lab and St Marks Wildlife Refuge. Panacea hosts events like the Blue Crab Festival and the Oyster Festival for good eating and entertainment.
Own a piece of Ole Florida, 10.98 acres surrounded by water and has a nice pond tied to the Bay so it is tidal. You would have a beautiful view of water and trees with a serene place to build a home. At the end of Levy Bay Rd is a boat ramp.
14.29 Acres in the heart or Panacea. Contains approximately 4.5 acres of uplands with a nice view over the remaining 10 acres of pond frontage. Nice high homesite recently mulched and partially cleared for easy access off a private drive. Just minutes to the saltwater but isolated, private, and protected. Two adjoining buildable lots on Lilly drive also for sale for an additional 12,000. See MLS Number 402074
Two adjoining building lots each 75x100 for a total of .34 acres. Located in the heart of panacea, just minutes from the saltwater and some of the best fishing in the state. Can be purchased with adjoining 14.29 acres see MLS number 402093
Build your dream waterfront retreat on Pompano Drive in beautiful Panacea! This exceptional Bayfront homesite offers direct access to the Gulf of Mexico, making it a paradise for boating, fishing, kayaking, and paddle boarding enthusiasts. Enjoy breathtaking sunrises and sunsets over the bay from your own backyard while embracing the laid-back charm of Florida's Forgotten Coast. Conveniently located just minutes from the beach, public boat launch, scenic bike path, local shops, waterfront restaurants, and charming art gallery, this property offers the perfect blend of tranquility and coastal convenience. Whether you're planning a full-time residence, vacation getaway, or investment property, this is your opportunity to own prime waterfront property in one of North Florida's most desirable coastal communities. Information deemed reliable but not guaranteed.
Welcome to 88 River Drive in Panacea, Florida—a charming coastal property where relaxed living meets the beauty of Florida's Forgotten Coast. Whether you're looking for a full-time residence, a weekend retreat, or an investment opportunity, this home offers the perfect setting to enjoy the laid-back waterfront lifestyle. Located just minutes from boat ramps, marinas, fishing, and some of the area's best seafood restaurants, you'll have easy access to everything that makes Panacea such a desirable destination. Spend your days boating, fishing, kayaking, or exploring nearby beaches and nature preserves, then return home to unwind in the peaceful surroundings. The property offers a comfortable layout with inviting living spaces, making it ideal for entertaining family and friends or simply enjoying quiet evenings at home. With its convenient location near the Gulf Coast and easy access to Crawfordville and Tallahassee, this home combines small-town charm with everyday convenience. If you've been searching for an affordable slice of Florida's coastal lifestyle, 88 River Drive is ready to welcome you home. New roof in 2025, Mini splits added 5 years ago, new windows in the downstairs area of the home. New stove (2025) New refrigerator (2024), New dishwasher (2022).
Welcome to Marina Village! This beautifully updated 1,332 sq ft end unit townhouse offers 3 bedrooms and 2.5 baths, along with a deeded boat slip complete with power and water. Enjoy bay views and refreshing sea breezes from the screened porches and mezzanine decks perfect for grilling and entertaining. The home features recent updates and an extended patio underneath, providing additional outdoor living space ideal for relaxing after a day on the water. Residents enjoy access to the newly built community pool, offering the perfect spot to unwind after fishing or spending time at the beach. Conveniently located just down the street from Mashes Sands Public Beach and boat ramp, the property also adjoins the scenic 16-mile Ochlockonee Bay bike and walking trail that winds along the water and through the St. Marks National Wildlife Refuge. With saltwater access, a boat slip, community pool, and low maintenance living, this property offers the ideal coastal retreat for full time living or weekend getaways.
Experience the beauty of Florida's Forgotten Coast from this exceptional Gulf-front homesite on Alligator Drive in Alligator Point. This buildable 0.41-acre lot offers breathtaking, panoramic views of the Gulf, creating the perfect setting for your dream beach home. Wake up to spectacular sunrises, spend your days enjoying world-class fishing, and watch pelicans, herons, shorebirds, and other native wildlife from your own front yard. Whether you're looking for a private coastal retreat, a vacation getaway, or an investment opportunity, this rare waterfront property offers endless possibilities. If you've been dreaming of life on the Gulf, this is your chance to own a slice of paradise.
This lot in the Refuge of Panacea offers privacy, gated community close to the Ochlocknee Bay. Come construct your dream home surrounded by natural landscapes. You have nearby beaches, marinas and great dining. Owner financing may be available with acceptable terms. All measurements are approximate.
Deep water bayfront lot in Ochlockonee Bay. Cant beat the view from this south facing lot, looking out over the unspoiled and undeveloped bay. All the land across the bay is government owned, over 36,000 acre St. Marks National Wildlife refuge and 28,000 acres of Nature Conservancy property. The view should never change and its one to die for. Great water depth allows for larger boats, and some of the best fishing in all of Florida is right in front of this lot. Water, sewer, and electric all available at this site. Unspoiled waterfront views, deepwater, and great fishing, what more can you ask for?
wooded light with frontage on coastal highway and chipola street
Old Florida Charm Meets Coastal Living in the Heart of Panacea Just a few blocks from the water in the historic fishing village of Panacea, this exceptionally maintained 3-bedroom, 2-bath home is more than a residence; it's a coastal headquarters for boating, entertaining, and enjoying everything the Forgotten Coast has to offer. Panacea is known for its authentic Old Florida character, world-class fishing, and easy access to the Gulf, making it a favorite destination for anglers, boaters, and anyone seeking a slower pace of life. Situated on three oversized lots, you'll have all the room you need for boats, trailers, RVs, golf carts, and all the equipment that comes with the coastal lifestyle, without feeling crowded. The owners have enjoyed the ultimate outdoor living space; the expansive covered patio has been thoughtfully designed with outlets for your game day TVs and dedicated areas for both grilling and smoking your fresh catch. An outdoor bathroom complete with a shower makes cleaning up after a day on the water quick and convenient. Need storage? This property delivers. A spacious, well-organized storage area with an elevated mezzanine provides abundant room for tools, fishing gear, seasonal décor, and workshop space. The entire property is fully enclosed with chain-link fencing, creating a secure space for pets, children, or simply peace of mind. Outside, tropical landscaping surrounds the home with vibrant flowering plants and fruit trees, creating your own oasis. Whether you're searching for a full-time residence, a weekend fishing retreat, or a place to gather family and friends after long days on the Gulf, this property offers the space, functionality, and relaxed coastal lifestyle that make Panacea so special. Come experience where every day feels like a weekend on Florida's Forgotten Coast.
Recently updated and move-in ready, this well-maintained mobile home in Panacea sits on a spacious 0.24-acre lot and offers both comfort and investment potential. Inside, you'll find fresh paint, durable luxury vinyl plank flooring throughout, and a desirable split-bedroom floor plan that provides privacy for family and guests. The spacious kitchen offers plenty of cabinet and counter space and opens to a cozy living area featuring a fireplace, creating the perfect gathering space. The primary suite has been beautifully updated with a custom tile shower, a separate soaking tub, and new bathroom vanities, giving it a modern, spa-like feel. Outside, enjoy a fully fenced backyard shaded by mature trees, ideal for pets, gardening, or outdoor entertaining. Additional features include a durable metal roof and ample outdoor space to enjoy the peaceful Panacea lifestyle. Whether you're looking for a primary residence, vacation getaway, or investment property, this home is worth a look. Previously used as a long-term rental, the property offers established rental income history and excellent potential for future investors.
Marina Village is a unique fishing and sporting community located on the Ochlockonee Bay and the Gulf of America in Wakulla County Florida. Eighteen townhomes, with boat davits, swimming pool with large covered area and well maintained grounds makes this a very special place live and enjoy.
Experience care-free Coastal living. Bayfront condo located in the Heart of Panacea. Enjoy resort-style amenities: community pool, tennis court, & gated entry. A scenic walking/bike path leads to quick & easy Beach/Boating access to enjoy the best of Florida’s Forgotten Coast lifestyle. Prime location for both sunrise and sunsets & the convenience to walk to the popular shops, restaurants, and art galleries. HOA fees provide exceptional value: covering insurance, the entire exterior maintenance of the building, groundskeeping, onsite laundry facility; affording true care-free ownership. Short-term rentals allowed, making this an excellent investment opportunity, vacation retreat, or full-time residence. Relaxed waterfront living where you can even ride your golf cart to restaurants, stores, the Beach & more...
Welcome to the fly-in, gated community of Tarpine, located just minutes from the coast. This lovingly maintained, single owner, open concept home has two levels with separate entrances on 3/4 of an acre. Homesite is on 1.5 platted lots. Top floor hosts 1 bedroom, 1.5 bath, office, laundry, kitchen/dining, living, sunroom, and porch. Bottom floor hosts 2 bedrooms, 1 bath, large flex room/office, family room, store room, and porch. Solid oak floors in living space upstairs, custom maple built-ins, and an open concept welcome you as you walk in. Home is bounded on the north by Stinson Taxiway (paved neighborhood access to the airport) and on the west by the runway of the Wakulla County Airport. Homeowners have access to a private bay front community lot with boat ramp on Ochlockonee Bay as well as front/back gated neighborhood access to Ochlockonee Bay Bike Trail. Fly in and fly out of Wakulla County Airport. Enjoy carport area, half circle drive, and a large paved driveway/parking pad. All measurements are approximate and to be confirmed.

The data relating to real estate for sale on this website comes in part from the Internet Data Exchange Program of Tallahassee Board of Realtors. The information is provided exclusively for consumers’ personal, non-commercial use, and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. The data is deemed reliable but is not guaranteed accurate.


Panacea is located in Florida. Panacea, Florida has a population of 1,050. Panacea is less family-centric than the surrounding county with 9.22% of the households containing married families with children. The county average for households married with children is 32.02%.
The median household income in Panacea, Florida is $31,976. The median household income for the surrounding county is $72,941 compared to the national median of $69,021. The median age of people living in Panacea is 46.6 years.
The average high temperature in July is 92.1 degrees, with an average low temperature in January of 37.9 degrees. The average rainfall is approximately 59.1 inches per year, with 0 inches of snow per year.