This is an exceptionally rare chance to secure a versatile mixed use commercial property in Islamorada's most established business corridors. With prominent highway frontage, excellent visibility, and steady traffic exposure, theses three building are ideally positioned for a wide range of commercial uses. making it an appealing option for investors and owner-operators. The building features a practical, adaptable layout suitable for professional offices, medical or wellness services, boutique retail, administrative operations, or specialty businesses. Large front-facing windows bring in natural light and enhance street presence, creating an inviting entry point for customers and clients. The footprint also supports the creation of private offices, treatment rooms, or storage areas, allowing businesses to tailor the space to their operational needs. On-site parking adds significant value, providing convenient access for customers and employees--an important advantage in Islamorada's commercial zones. Excellent signage opportunities ensure strong brand exposure. Easy ingress and egress make the location suitable for both destination-based and walk-in business models. Surrounded by established businesses, restaurants, marinas, and residential neighborhoods, the property benefits from a diverse and active customer base. Islamorada's strong local economy enhances the long-term appeal of this location. Totally renovated in 2019. Business is not part of thr sale.
A-1 Urgent Care & Family Practice Center - Islamorada, Florida KeysAre you a Doctor looking to purchase an established practice or know a Doctor in the Market? This Medical practice has ben established for 20 years and has steadily grown over time.Located in Islamorada, there are few other medical offices for clinics or pediatrics making this a very interesting opportunity for any interested Medical personnel.
74560 Overseas Highway is a dynamic waterfront commercial asset with multiple revenue paths and significant redevelopment potential. Situated on a 15,000 SF parcel with generous on-site parking and 100 feet of seawall capable of accommodating up to 8 slips, the property delivers premier highway exposure and immediate Florida Bay and Atlantic Ocean access. Zoning supports four affordable housing units, one market-rate residence and 5,640 SF of commercial space, creating a layered income strategy that blends residential density with marine-oriented business activity. Commercial fishing zoning allows for uses such as a restaurant, seafood market, marine outfitter, charter or fishing headquarters, or other enterprises aligned with the working waterfront.
Courtesy: Coldwell Banker Schmitt RE Co
305-743-5181
Prime downtown Islamorada commercial property featuring 5,232 SF of retail space across four bays on a 15,000 SF large corner lot with excellent US-1 frontage. More than 50 years of continuous retail use makes this a well-known and highly visible location with both strong drive-by exposure and pedestrian access. Village Center zoning allows for future expansion or mixed-use possibilities, including second-story development or workforce housing (subject to approvals). Two long-term tenants are currently in place and would like to remain, offering stable income for the next owner. The third and fourth bays are currently vacant and available for immediate use or lease -- an ideal opportunity to secure new tenants or owner occupancy before the holiday season.
Step into a thriving turnkey upholstery business established in 1972 in the heart of Islamorada! A prime canal front location with water access & 26' dockage-clients even arrive by boat! 50 years in business! This long standing operation has built a stellar reputation serving both locals and seasonal residents with expertise in interior, exterior, furniture & full marine upholstery needs. This Business sale comes fully equipped with 2 sewing machines, compressor, fabric inventory, supplies & all necessary tools. Established name, logo, website & brand identity transfers with sale. Rare opportunity to live & work in paradise! Perfect for an owner-operator or entrepreneur seeking a lifestyle business in the Florida Keys! Owner will stay on for a short period to train and transition if needed
Amazing BUSINESS Opp built over the past 5 yrs in the heart of Islamorada & the Keys (Ocean Reef to Big Pine Key) A Street Legal (Old Hwy) Golf Cart Rental Co ready for its new owner to ROLL with! Included in this Business Sale: 7 Luxury Golf Carts Lithium ECO Battery & Gas Carts valued at appx 14k ea. They are 2023 or newer which sell for appx 20k per cart- 8X16 Single Wide Trailer valued at appx $2K-tent valued at appx $5K. Also included: Name, Logo, Website, All Social Media, Marketing, Phone Number & Clients. Current owner will work with new owners making sure all networks built over decades of Keys experience and knowledge is passed on. Expenses are limited to Rent, Insurance and Phone. There are no other golf cart rental companies like it in the Upper and Middle Keys! RIDE in Style!
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All listings featuring the BMLS logo are provided by BeachesMLS, Inc. This information is not verified for authenticity or accuracy and is not guaranteed. Copyright © 2026 BeachesMLS, Inc.
Islamorada is located in Florida. Islamorada, Florida has a population of 7,051. Islamorada is less family-centric than the surrounding county with 18.45% of the households containing married families with children. The county average for households married with children is 20.65%.
The median household income in Islamorada, Florida is $77,423. The median household income for the surrounding county is $73,153 compared to the national median of $69,021. The median age of people living in Islamorada is 55.3 years.
The average high temperature in July is 89.3 degrees, with an average low temperature in January of 62 degrees. The average rainfall is approximately 47.7 inches per year, with 0 inches of snow per year.
