Step into a rare opportunity to own a piece of local history with modern versatility. Originally built in 1885, this charming historic home blends timeless character with numerous updates that enhance both comfort and functionality. Ideally situated on the town’s main thoroughfare, the property offers exceptional visibility and accessibility—perfect for a variety of commercial uses. Inside, you’ll find a thoughtfully updated interior that retains its classic architectural details while incorporating contemporary improvements. The flexible layout lends itself seamlessly to professional office space, boutique retail, or a live/work setup. Generous rooms can be configured for private offices, meeting areas, or client-facing spaces. The property is currently zoned residential but is located in the Melrose Rural Cluster and therefore could be rezoned for a business use. "Rural Cluster" is a type of zoning that allows more flexibility than typical zoning- it would allow small-scale businesses - so long as it stays low-impact and fits the rural character of the area. Adding to its appeal, the property provides the unique option for an owner-occupant to live on-site, making it an ideal choice for entrepreneurs or small business owners seeking convenience and efficiency. Whether you’re looking to establish your business in a high-traffic location or invest in a distinctive property with dual-use potential, this historic gem delivers unmatched charm, visibility, and opportunity. Seller is open to owner financing.
This is an open, active, and vibrant family medical practice for sale, looking for a new owner to service this community located less than 30 minutes from Gainesville. With over 2,000 patients and a twenty-year history of both family practice and obstetric care this established primary care practice is a turnkey operation. This well-kept facility has 20 rooms with 6 exam rooms including two large rooms, a three sectioned reception area, a large administrative office with six workstations, nursing station, lab draw room and three bathrooms. Practice assets both tangible and intangible are included with the property. This site has been a Rural Health Center and remains eligible to stay in the RHC program along as an NHSC site for loan repayment for those providers needing assistance.
The Melrose Center consists of two to of the most attractive buildings located in the heart of Melrose. The buildings represent a limited selection of commercial property that faces the main thoroughfare of Hwy 26, a major roadway running from Gainesville to Putnam Hall Fl. The front building, “The Studios of Melrose” consists of eleven mixed use offices ranging from health care providers to artist studios, to a multi-room art gallery. The building represents the Victorian four-square design that is a historic standard throughout the town. The Center is licensed as a fifty-seat full service restaurant with both inside and outside eating areas. The kitchen was fully renovated in 2021, with much of the equipment upgraded to brand new condition. The facility has both inside and outside stages which are used to showcase musicians on a weekly basis. The inside hall is also used to showcase local artists’ work. Certified by Visit Florida The Welcome and Information Center is officially certified by Visit Florida—a recognized State of Florida designation. It serves the broader Lake Area Region spanning Gainesville, Ocala, Palatka, St. Augustine, and Jacksonville, and is affiliated with all statewide Welcome Centers through Visit Florida. Unmatched Visibility Located between I-75 and I-95, this site sees 8,000–10,000 cars daily. It's not any ordinary spot – it's a combination restaurant, art house, and community gathering place. If you've ever dreamed of owning a place where food and art come together - the Melrose Center might just be your perfect opportunity.
Melrose commercial opportunity- Located one block from the junction of SR 21 & SR 26 in the heart of Melrose is the perfect site to start your new retail or service business. With 100 feet of SR 21 frontage, this 0.31 acre site offers great exposure with a traffic count of over 9,500 cares daily. Zoned C-2 commercial the site offers city water, and is flat and ready to build. The vibrant community is known for its many community events and art shows that can swell foot traffic dramatically on the weekends. So, if you have been dreaming of starting your own business don't let this unique opportunity pass you by!


Melrose is located in Florida. Melrose, Florida has a population of 6,019. Melrose is less family-centric than the surrounding county with 16.28% of the households containing married families with children. The county average for households married with children is 18.89%.
The median household income in Melrose, Florida is $58,929. The median household income for the surrounding county is $39,975 compared to the national median of $69,021. The median age of people living in Melrose is 57.2 years.
The average high temperature in July is 91.4 degrees, with an average low temperature in January of 41.7 degrees. The average rainfall is approximately 51.1 inches per year, with 0 inches of snow per year.