Courtesy: 573 Realty Group
573-547-1000
Position your business for success with this highly visible Main Street commercial property located among several established and successful businesses. Recent improvements include a new roof installed in April 2026 and a ceiling-mounted gas furnace added in 2025, providing peace of mind for years to come. The property spans from Main Street to Spring Street, offering valuable access for customers, deliveries, and operations. Large storefront windows along Main Street provide excellent exposure and merchandising opportunities, making this an ideal setting for retail sales, product displays, or customer-facing businesses. Inside, approximately 2,100 sq ft of open retail space offers flexibility to tailor the layout to your specific needs. A half bath is centrally located in the building. All existing shelving will remain, allowing a new owner to begin operations with minimal expense. The warehouse area provides an additional 1,344 sq ft of space, complete with a machine room. Overhead doors on both the side and rear of the building allow for convenient loading, unloading, and inventory management. With C-2 zoning and a versatile floor plan, this property is well suited for retail, office space, an art gallery, convenience store, specialty shop, service business, or countless other commercial ventures. Bring your vision and take advantage of this prime location and adaptable space.
Courtesy: Area Properties Real Estate-Midsouth
573-579-7653
Location is hard to beat with this nearly 7,000 sq foot commercial building in the heart of downtown Perryville. Completely rehabbed over the past four years, this property offers endless possibilities. Whether you're looking to create multiple retail spaces, open an event center or venue, or establish a restaurant, this building can accommodate a wide variety of business ventures. Situated on 0.451 acres, the property also provides multiple parking spaces, an amenity that can be difficult to find. Bring your vision to life and take advantage of the momentum and growth happening in downtown Perryville
Courtesy: 573 Realty Group
573-547-1000
Exceptional commercial opportunity on 1.79 acres of C-2 zoned property featuring two buildings, ample parking, and a versatile layout suited for a variety of business uses. The primary building offers approximately 9,600 sq ft plus a 1,600 sq ft lean-to. Approximately 3,200 sq ft is finished office/showroom space, while the remaining 6,400 sq ft consists of open warehouse/shop space currently used for automotive operations. The showroom features a large service counter, built-in workstations, and oversized double doors allowing vehicle access from the shop area. Additional amenities include an office, vault, parts/storage room, break room, half bath, utility room, security system, and geothermal HVAC. Loops are already installed for a second geothermal unit. The warehouse/shop area features 10-foot ceilings and three overhead doors, including one with a gravel ramp and loading dock beneath. Two additional doors are located under the lean-to, one with a small dock. Three-phase power can be reconnected. The second building, constructed in 2018, measures 50x120 (6,000 sq ft) and includes four 12' x 14' overhead doors plus three open bays ideal for equipment, fleet, RV, or contractor storage. Two enclosed bays are leased at $225/month each and include heat and electric. Additional features include a large asphalt parking lot, fenced yard, corner lot location, and flexibility for automotive, retail, contractor, warehouse, storage, or office use.
Courtesy: 573 Realty Group
573-547-1000
Commercial opportunity near the Highway 51/61 junction! This 1.056 acre property is zoned C-2, offering flexibility for a variety of potential uses. Continue utilizing it as a residential property with some updates and improvements, or explore the possibilities for your next business venture. 1346 sq ft home with 32 x 36 detached garage. High-visibility location with excellent accessibility and potential in a growing commercial corridor.
Courtesy: Landmark Real Estate Group Residential
314-965-9110
This one checks a lot of boxes for a business owner or investor looking for space, flexibility, and visibility. Sitting on 5.16+/-; acres just outside Perryville city limits, this property opens the door to even more possibilities with fewer restrictions and room to grow. The main business center features 8 offices, a reception area, spacious conference room, 2 vaults, kitchen, storage rooms, half bathrooms, product showcase space, and a 48x52 attached garage. The garage includes a half bath, electric, furnace, and overhead doors. You’ll also find an additional 88x24 outbuilding with gravel floors, electric, 2 enclosed bays, and 1 open lean-to area. Multiple entrances, two parking areas, and excellent access make this setup ideal for a variety of business operations. An added bonus? Solar panels are already in place, helping reduce utility costs and lower your business overhead even more. Located just minutes from Perryville and less than a mile from Highway 61, you can easily reach Fruitland, Jackson, and Cape Girardeau while still enjoying the advantages of being outside city limits. PCR 500 is newly paved, making access smooth and convenient.
Courtesy: AgriBuck Properties
573-513-5701
Prime Commercial Opportunity on Highway 61 – Perryville, MO Seize the chance to own a commercial property with outstanding potential along the highly traveled Highway 61 in Perryville. This vacant building is being sold as-is, offering a blank slate to bring your business vision to life. With excellent highway frontage and visibility, the property ensures maximum exposure for future customers. Whether you’re looking to establish retail, office space, service business, or invest for future development, this location offers versatility and opportunity. Don’t miss out on this affordable entry into a high-traffic commercial corridor—schedule a showing today and imagine the possibilities!
Courtesy: Preferred Realty
573-768-3770
Prime commercial opportunity just minutes from the interstate! This highly visible property, located approximately 1/4 mile off the exit, offers excellent access and exposure for a variety of business ventures. Situated on a little over an acre, the lot provides ample space for development and flexible layout options. Ideal for a convenience store, gas station, Dollar General, storage units, or other retail or service-based businesses, this property is perfectly positioned to capture both local and highway traffic. Electric is readily available, making it even easier to bring your vision to life. Whether you’re looking to start a new business or expand your investment portfolio, this location offers outstanding potential in a growing and accessible area.
Courtesy: Lorimont L.C.
573-334-5200
21,510 SF building with office/showroom & shop/warehouse area, along with a 6,552 SF rear industrial shop building on 18 acres of property. With 10 overhead doors, 1 loading dock door, and security fencing, this property offers versatility for various business endeavors. Property also contains a separate large security-fenced equipment storage yard with access to the I-55 Outer Road.
Courtesy: 573 Realty Group
573-547-1000
Income-Producing Commercial Investment / 1.63 Acres / High-Traffic Location Prime opportunity to acquire 1.63 acres of commercially zoned land with an established, income-producing water and ice vending business in a high-visibility, high-traffic corridor. The existing equipment occupies only 16' x 10', allowing the majority of the parcel to remain available for additional development or expansion. The business currently generates approximately $25,000 of net income annually with growth potential. Equipment is modern and in place, providing immediate cash flow from day one. The site is fully improved with water, sewer, and 3 phase electric, including additional hook ups to accommodate three food trucks or other small business, creating additional income opportunities or enhanced development flexibility. There are 6 security cameras on the exterior of the ice machine and 2 on the inside. A very robust system with license plate identification and sound detection. This property offers a compelling combination of passive income, land appreciation, and future development potential, making it ideal for investors seeking stable returns with upside.
Courtesy: Edge Realty
573-335-8111
Opportunity to own a well known commercial property in the heart of downtown Perryville. This approximately 14,400 square foot building sits on a large lot and is currently tenant occupied by The Alley Cat Lanes and Lounge, providing an established presence and built in income potential. The property offers excellent visibility, ample space, and a prime location surrounded by local businesses, dining, and community activity. Ideal for investors or buyers seeking a sizeable commercial footprint with an existing tenant in place.
Courtesy: Edge Realty
573-335-8111
Rare opportunity to acquire a multi tenant, mixed use property totaling over 20,000 square feet, ideally located on the square in downtown Perryville. This beautifully designed property features eight residential units, with a mix of short term rentals currently operating as Airbnbs and long term residential leases, offering diversified income streams. The property also includes four fully leased commercial units that have seen extensive improvements, including major structural updates such as electrical and HVAC systems, providing peace of mind for future ownership. Positioned in a prime downtown location with strong visibility and consistent tenancy, this is an exceptional investment opportunity with established cash flow and long term upside.
Courtesy: Edge Realty
573-335-8111
Looking for a turn key, fully operational business in the heart of Perryville? The Mediterranean House presents a rare opportunity to own a luxury property designed to host unforgettable stays and events. Currently operating as a successful and versatile venue, this property is well suited for use as an Airbnb, bed and breakfast, or a destination for corporate retreats, wellness or yoga getaways, and private events. The home features six beautifully appointed bedrooms, four full bathrooms, and one half bathroom, offering ample accommodations for guests. A commercial grade kitchen equipped with stainless steel appliances is ready to support culinary experiences, from baking and cooking workshops to catered events. All furniture stays, including antique furnishings, bedroom suites, dining room suites, etc. With its flexible layout and elegant setting, The Mediterranean House is ideal for bridal and baby showers, birthday celebrations, intimate gatherings, or larger hosted events. This is a truly turn key business opportunity, ready for immediate operation, offering the space, functionality, and charm to bring a wide range of visions to life.
Courtesy: 573 Realty Group
573-547-1000
Position your business for success with this exceptional C-2 zoned 2.26-acre property offering highway frontage, strong visibility, and steady traffic flow along the Highway 51 corridor. Located in an area experiencing recent development, this site is well-positioned for continued commercial growth and accommodates a wide range of potential uses. The property includes a 1,727 sq ft, 3-bedroom home with a full basement, providing flexibility for owner occupancy, office conversion, or on-site operational space during future development. Also included is a 30x56 fully insulated metal outbuilding, constructed in 2018 by Ponder Built, featuring 12-foot ceilings, insulated overhead doors, concrete floor, metal-lined interior, bathroom with slop sink and toilet, permanent automotive lift, air compressor with plumbed air lines, and 3.5-ton HVAC unit with dehumidifier for year-round climate control. This building is potentially suited for a variety of commercial operations. An existing billboard lease adds additional income potential. With its strong exposure, zoning, and versatile improvements, this property offers an outstanding opportunity for investors, developers, or owner-users seeking a high-visibility commercial site along a proven corridor. Duplicate listing 25080826
Courtesy: AgriBuck Properties
573-513-5701
Historic Commercial Gem on the Square – 1859 Brick Building, Fully Restored & Modernized Step into a piece of local history! Built in 1859 as the first brick building on the square, this remarkable commercial property beautifully blends timeless character with complete modern functionality. Every inch of this building has been thoughtfully updated while preserving its historic charm. Property Highlights: Fully replumbed, rewired, and reroofed — truly turnkey and up to code HVAC system updated with central air, plus mini-splits for added comfort and efficiency All new windows and complete tuckpointing inside and out for long-term durability Trim lighting around the roof adds modern curb appeal to the historic façade Water softening system is owned and professionally maintained through a service program Additional lot space with direct access off S. Jackson Street—ample room for constructing an additional building, expansion, or added parking options Currently houses three separate office spaces, an operating salon, and three Airbnb units on the upper level—providing immediate income potential Interior Features: Welcoming reception and waiting areas ideal for client interaction Multiple private offices and break rooms for staff comfort and productivity Functional layout suitable for professional offices, retail, hospitality, or mixed use This building stands as a cornerstone of history—the first brick structure on the square—but offers the peace of mind of a fully updated, code-compliant property. With existing income-generating spaces and bonus expansion potential on the adjoining lot, it’s perfect for buyers who value historic charm, modern reliability, and room to grow.
Courtesy: RE/MAX Realty Experts
573-547-8385
Day Care Building for Sale – Turnkey Opportunity! Looking to own your own day care or expand your childcare business? This ready-to-go day care facility offers everything you need to get started right away! Property Highlights: 1,344 sq. ft. main level designed for day care use; 3 bathrooms for convenience and compliance; Kitchen area plus dining space for meal and snack times; All day care contents included (if buyer continues to use as a day care); Appliances included: stove and 2 refrigerators, microwave; Large fenced playground area – safe and perfect for outdoor fun; Unfinished lower level provides room for storage or future expansion; Small shed included for extra storage; Updated HVAC system plus 2 window A/C units for year-round comfort. This property is move-in ready for your day care business — everything you need is already in place! Whether you’re an experienced provider or starting a new venture, this is a rare opportunity to own a fully equipped child care facility.
Courtesy: RE/MAX Realty Experts
573-547-8385
4040 +/- SF Downtown Perryville Commercial Building – Fantastic investment opportunity! This prime corner-lot property features 4 rentable units with excellent income-generating potential. The building includes a full 4040 +/- sq. ft. walk-out basement, perfect for storage, expansion, or conversion into additional rental space for added income. With high street visibility and convenient street parking plus extra parking at the basement level, this property offers great accessibility. Ideal for professional offices, boutique retail, or mixed-use tenants, it provides flexibility for a variety of business opportunities. Don’t miss this chance to secure a solid income property in a high-traffic downtown location!
Courtesy: Re/max Realty Experts
573-547-8385
Motivated Seller says Make Reasonable Offer! Are you looking for a new location that has a ton of daily traffic to further promote your business? This property is located on the corner of State Highway 61 and Highway E, providing an AADT count of 4,085 daily passersby in 2023. The building offers 1488 sf of space which is currently utilized as a completely remodeled office space with a warehouse and full bathroom. The property has undergone significant updates including a metal roof, wiring and plumbing as well as all new insulation, gutters and much more. This building has potential for so many uses with the ability for expansion into the warehouse area. Let your dreams take shape with this affordable investment! Location: City, Corner Location, High Traffic
Courtesy: Land Xchange Inc
636-797-8257
Great laying property located just off Highway 55 with highway visibility, land lays incredibly flat and is zoned C-2 which offers a wide variety of uses, from a restaurant, hotel, Apartments, and far to many more to list. Under the C-2 zoning the C-1 is also in play with many other types of uses. There is already a water easement in place on the South end of the property and a couple of options to bring in sewer. There is a small cut out of the property with 2 billboards that is not part of the property, but does have a smaller billboard sold with the property. If you are looking to expand an existing business or a new start up company this is a great opportunity in a fast growing area. Location: City, High Traffic, Hwy/Interstate Frntg
Courtesy: Re/max Realty Experts
573-547-8385
Excellent .94 acre commercial development potential. Easy access to both I-55 and the vibrant downtown of Perryville. Great location in a high traffic area and makes a nice site for any type of business including restaurant, office, or retail. 180 feet of road frontage. Nearby businesses include: Walgreens, Scooter’s Coffee, Midwest Total Urgent Care, and Perryville Tire. Value-added site improvements have already been completed to bring this tract to a ready standard for any build-to-suit or custom prospect. Appropriate ingress / egress access. The property is zoned C-2 in a strategic location prime for new development with easy access to major thoroughfares. The current business in this property in not closed and will remain in business for one year from sale date. Location: City, Corner Location, High Traffic, Hwy/Interstate Frntg
Courtesy: Lorimont L.c.
573-334-5200
23.86 acre corner lot ready for development in growing area of Perryville with excellent traffic and visibility. Suitable for various uses. Close to industrial businesses. Currently not in the city limits, but city utilities are nearby for easy annexation. Location: Corner Location, Hwy/Interstate Frntg, Industrial Park, Industrial Area
Courtesy: Lorimont L.c.
573-334-5200
9.45 acres ready for development near Missouri's National Veterans Memorial. Suitable for various uses. City utilities nearby and close to industrial businesses. Location: Hwy/Interstate Frntg, Rural
Courtesy: Lorimont L.c.
573-334-5200
3.7 acre corner lot ready for development in north end of Perryville with excellent traffic and visibility on Highway 51. Suitable for various uses. Currently not in the city limits, but city utilities are nearby for easy annexation. Location: Corner Location, Hwy/Interstate Frntg
Courtesy: Lorimont L.c.
573-334-5200
2.39 acre corner lot ready for development in north end of Perryville with excellent traffic and visibility at the intersection of Highway 51 and N. Main St. Suitable for various uses. Perfect for C-store. Currently not in the city limits, but city utilities are nearby for easy annexation. Location: Corner Location, Hwy/Interstate Frntg
Courtesy: 573 Realty Group
573-547-1000
Check out this subdivision already established with utilities, sidewalks, street lights, streets, and restrictions. 15 lots remain and are already platted. This is a great opportunity to develop or sell lots individually for the next buyer to build to their liking. With this being the only subdivision offering lots, the possibilities are endless. Four homes have already been built and sold. The demand for housing in Perry County makes this a no brainer. Location: City
Courtesy: 573 Realty Group
573-547-1000
COMMERCIAL BUILDING & LAND! Seize this exceptional commercial property in a high visibility location, just blocks from downtown and directly across from the newly built Justice Center. This property features a spacious reception area, supply room, full kitchen, 1.5 bathrooms, a file room and 7 private offices. Additionally, there is an income generating opportunity with three vacant rental spaces you could maximize revenue. With three separate exterior entrances, the space offers flexibility for multiple tenants or business uses. The existing carport could also be enclosed for additional storage. Looking for something different? Take advantage of the C-2 zoning and prime location to customize build your ideal business venture. Whether you're expanding, relocating, or investing, this property offers endless possibilities on the corner with over 300' of road frontage. Currently generating monthly income through leases. Location: City, Corner Location, Downtown, High Traffic
Perryville is located in Missouri. Perryville, Missouri has a population of 8,482. Perryville is less family-centric than the surrounding county with 30.51% of the households containing married families with children. The county average for households married with children is 32.72%.
The median household income in Perryville, Missouri is $50,774. The median household income for the surrounding county is $56,832 compared to the national median of $69,021. The median age of people living in Perryville is 38.2 years.
The average high temperature in July is 89.1 degrees, with an average low temperature in January of 21.7 degrees. The average rainfall is approximately 44 inches per year, with 7.3 inches of snow per year.
