PRIME COMMERCIAL OPPORTUNITY IN THE HEART OF TOWN! Endless possibilities await with this spacious 7,200-square-foot commercial building situated on THREE city lots! Featuring a NEW ROOF and HVAC system, this property was most recently operating as a daycare with 10 rooms, offering a versatile layout ready for its next chapter. Interior features include multiple spacious rooms, reception area, kitchen space, and plenty of room for offices or specialized services. Outside, you'll find ample paved parking, covered areas, and a large fenced outdoor space. With excellent road frontage and a convenient central location, this property offers outstanding visibility and accessibility. Whether you're envisioning a medical office, therapy clinic, assisted living facility, educational center, or another business venture, the possibilities are tremendous! All potential uses are subject to applicable zoning, licensing, and approval requirements. Don't miss this incredible investment opportunity
For businesses or individuals contemplating relocation or new ventures, this lot is a prime find. With visibility from interstate 59, Exit 6 and easy access from the service road, its location is highly desirable. Furthermore, its short drive to the Hospital, new Police station, shopping, downtown Picayune enhances its appeal. This lot is a rare find that should not be passed over. Commercial Land Cooper Road facing I-59 Interstate.
Rare Find! Previously used as Doctors Office. This property is zoned Office Professional. There is ample parking. The property adjoins the back side of County Offices. There are many possibilities for this property. There are no less than 8 exam rooms, a kitchen, file room, two waiting areas and much more.
Excellent commercial opportunity! This 6,878-square-foot commercial building, currently home to New Sunflower Grocery Store, is situated on approximately 1.22 acres on Palestine Road. The property offers ample parking and convenient access, providing an excellent location for a variety of commercial possibilities. With nearly 6,900 square feet of space and a generous 1.22-acre lot, this property offers plenty of potential for an investor, owner-operator, or business looking for room to grow. Take advantage of this opportunity to own a well-established commercial location and bring your vision to life. Sale includes real estate only--building and land. Business is not included in the sale. "Plat & Survey should be relied on for property boundary lines. MLS pictures are not deemed reliable for identification of property and should not be relied on by Buyer"
2025 Metal Commercial Building Food Processing, Retail & Office Opportunity Prime commercial opportunity in Picayune, MS! This 2025 metal commercial building features a brand-new interior build-out completed in 2026, and the owner has never occupied the property. Everything is new and thoughtfully designed for a variety of business uses. The interior features 10' drop ceilings, LED lighting, sealed floors and baseboards, two large rooms finished with FRP board on the walls and ceilings for food-processing applications, two large sinks, a three-compartment sink, dedicated hand-washing sink, and two A/C systems. Spray-in foam insulation provides an exceptional thermal envelope, creating an interior environment designed to retain temperature like an ice chest. Additional features include a welcoming lobby, conference room, large fiber-reinforced cement parking lot, and three steel-structure overhangs providing valuable covered exterior space. The flexible layout offers excellent potential for food processing, office space, retail, or other commercial uses. Conveniently positioned just of Hwy 11, the property offers easy access, consistent traffic flow, and excellent visibility---an ideal fit for a business seeking accessibility and local exposure. Turnkey, all-new construction ready for its next business venture!
Welcome to 521 West Canal Street in Picayune, Mississippi--a charming commercial property located on the highly sought-after West Canal strip. This property offers a fantastic opportunity for an entrepreneur, investor, or business owner looking for a convenient and established location. Currently operating as a hair studio, this adorable commercial building sits on nearly half an acre and is full of character. Inside, you'll find beautiful original hardwood flooring complemented by vinyl plank flooring throughout, creating a warm and inviting atmosphere. The versatile layout offers endless possibilities and could easily accommodate a variety of businesses. Continue its use as a salon or transform the space into an attorney's office, insurance agency, professional office, boutique, or other small business. With its desirable West Canal location, charming interior, and room to make the property your own, this is a commercial opportunity you don't want to miss!
**100 Elizabeth Street Picayune, Mississippi** **Multifamily Investment Opportunity** This six-unit multifamily property presents an exceptional investment opportunity in the heart of downtown Picayune. Offering stable in-place cash flow, multiple income streams, and immediate upside potential, this asset is well-positioned for investors seeking long-term income and operational flexibility. Property Highlights * Six-unit multifamily property * Three 2-bedroom, 1-bath apartments * Three 1-bedroom, 1-bath apartments * Prime downtown corner location with dual street frontage * Adjoining parcel included for dedicated tenant parking * Municipal utilities * Located in Flood Zone X * Zoned C-2 Downtown Commercial Income-Producing Features * Established rental property with documented operating history * Diversified income through both traditional apartment rentals and an existing furnished corporate rental * Furnished corporate rental has generated income through Airbnb, VRBO, direct bookings, and corporate stays * Furnishings convey with the sale, allowing the next owner to continue operations immediately without additional capital investment * ALL UNITS ARE FULLY LEASED as this property has the Advantage of the property's downtown location which provides convenient access to restaurants, retail, and local businesses, supporting both long-term residential leasing and furnished corporate rental demand. Market conditions indicate low vacancy rates, limited concessions, and strong rental demand, reinforcing the property's stable operating profile. With a balanced unit mix, multiple revenue sources, dedicated off-street parking, and a documented history of income production, this property offers investors a combination of current cash flow and near-term growth potential. Its stabilized operating performance is supported by actual rental income and recurring operating expenses, providing a strong foundation for long-term investment ownership.
Versatile commercial property situated on a prominent corner lot in Picayune. Offering approximately 1,413 square feet, the building features three bedrooms or private offices, two bathrooms, a kitchen, laundry room, dining room, living room, and an enclosed sunroom with heating and air conditioning. Previously used as a daycare/nursery facility, the layout offers potential for office, professional, educational, or other permitted commercial uses. This property is in need of TLC and is being sold strictly "As Is," with the seller making no repairs. Bring your vision and transform this space into your next business location or investment opportunity.
9.60+/- Acres of Prime Commercial Development Opportunity! An exceptional opportunity to own approximately 9.60 acres of high-visibility commercial property in one of the fastest-growing areas around. With Interstate 59 less than one minute away and State Highway 11 just moments from the property, this location offers outstanding accessibility and exposure. Surrounded by established businesses and essential services--including a hospital, police department, grocery store, gas stations, restaurants, and other commercial development--this property is perfectly positioned for future growth. Whether you're envisioning: Medical or professional office space Retail or shopping center Restaurants or fast-food franchises Hotel or hospitality Mixed-use development Business park or investment opportunity ...the possibilities are virtually endless. The property consists of five contiguous parcels being sold together for a total of approximately 9.60 acres (per tax records). Survey available for review. If you're looking for a premier commercial site with unbeatable access, visibility, and surrounding amenities, this is one you won't want to miss. Listing agent is related to the seller.
For businesses or individuals contemplating relocation or new ventures, this lot is a prime find. With visibility from interstate 59, Exit 6 and easy access from the service road, its location is highly desirable. Furthermore, its short drive to the Hospital, new Police station, shopping, downtown Picayune enhances its appeal. This lot is a rare find that should not be passed over. Commercial Land Cooper Road facing I-59 Interstate. Measurements are not warrantied. Plat and Survey should be relied on for property boundaries; MLS pictures are not deemed reliable for identification of property and should not be relied on by Buyer.
Great Business Opportunity with High Visibility! This property has been remodeled with many features added. Site work has been completed to improve a portion of the ground to support heavy equipment. There is single phase electrical that converts from single phase to 3-phase, electrical step-up transformer from 230 V to 480 V, completely fenced and circle driveway with 2 each 32 ft. entrances just to mention a few improvements. The building has a new HWH and a/c unit installed 2025, new metal roof installed 11-2024 and City grinder system. There is a kitchenette, 2 each half baths, 3 offices and a storage room.
High visibility commercial property fronting I59 South exit 4 ramp. Access to property is from S. Loftin Street off of Memorial Blvd.
This is Tract #7. Great location with high visibility. Located just north of Highland Hospital with restaurants and shopping in immediate area.
Andrea D. Conner, License 22561, Xome Inc., License 21183, [email protected], 844-400-XOME (9663), 750 State Highway 121 Bypass, Suite 100, Lewisville, TX 75067

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Picayune is located in Mississippi. Picayune, Mississippi has a population of 11,777. Picayune is less family-centric than the surrounding county with 16.6% of the households containing married families with children. The county average for households married with children is 27.91%.
The median household income in Picayune, Mississippi is $33,192. The median household income for the surrounding county is $53,855 compared to the national median of $69,021. The median age of people living in Picayune is 39 years.
The average high temperature in July is 90.5 degrees, with an average low temperature in January of 38.8 degrees. The average rainfall is approximately 62.6 inches per year, with 0.1 inches of snow per year.