Prime business opportunity in the heart of downtown Lancaster! This versatile commercial building offers an ideal setup for multiple businesses or a single expanding operation. The property features two floors, each thoughtfully designed with four offices and a half bath. The building has a total of 16 rooms and four half baths. Conveniently located just minutes from Highway 521 and Highway 9, this property offers excellent accessibility for clients and employees while being positioned in the center of Lancaster’s growing business district.
Versatile mixed-use opportunity located on high-visibility South Catawba Street in Lancaster. This unique property offers flexibility for residential or commercial use, making it ideal for investors, small business owners, or those seeking live/work potential. Inside, you’ll find spacious bedrooms and beautiful hardwood floors throughout, creating a warm and inviting atmosphere whether used as a home or professional space. The fenced backyard provides additional outdoor space perfect for entertaining, gatherings, or potential expansion opportunities. Positioned in a high-traffic location, the property offers excellent exposure for a tenant business and long-term value growth. Whether you're looking to establish a business presence, generate rental income, or own a flexible-use property with room to add value, this is an opportunity you don’t want to miss.
Prime Development Opportunity – Rezoned NB (Neighborhood Business). Exceptional large parcel recently rezoned NB (Neighborhood Business), offering outstanding potential for commercial or mixed-use development. Strategically located between Highway 521 and Kershaw Camden Highway, this property provides excellent visibility and accessibility. Road frontage on both streets for easier capabilities of splitting the property. Conveniently situated less than 3 miles from Downtown Lancaster, the site is positioned for strong growth and community connectivity. Water hydrants are located along the Kershaw Camden Highway side of the property, adding valuable infrastructure advantages. This is the same listing as MLS 4353097
Get ready to own your own business, convenience store located on the inner bypass 4-lane, lots of traffic, sell includes the building, land and inventory as of day of closing. Large refrigeration units, cold meat storage, meat slicer, scales, cash register, shelves with inventory everything needed to walk in and start your business. The building has had lots of upgrades to include new roof, trusses, new electrical panel, HVAC is older but was just serviced with new parts. Owner has taken good care of the building. There are 2 restrooms, large storage rooms, office space and table and 4 chairs . The seller would also entertain a lease for purchase option if terms can be agreed on. Seller will consider lease option.
Zoned B-2, Neighborhood Commercial, zoning would allow property to be occupied as a residence and operate a business also, Attractive, low maintenance building. Brick veneer, metal roof, Reception area, 2 offices freshly painted, 2 rest rooms, 867 square feet open area for storage or divide for additional offices. Partially fenced parking area at rear of lot. Heat pump & water heater 7 years old. 200 Amp Svc,220 receptacles available. Handicap accessible, 15 parking spaces beside building additional spaces at rear of building.
Prime commercial lot off busy Highway S 200!! For a business, this lot provides a terrific location and excellent visibility. This parcel has county water connected, an electrical box onsite and county sewer available (tap fee required). Minutes away from major roadways, shopping, business centers and MORE! Zoned for General Business, this parcel offers endless opportunities to build or to invest. Storage shed on property is included. Trees on property are a mix of hardwoods AND bamboo! GREAT VALUE - MUST SEE and easy to walk!
Great opportunity for investors. 7.49 acres, partially cleared. This property is located approximately 15 minutes S from downtown Lancaster and approximately 15 minutes N to shopping in Indian Land. This is a prime area for a single family residence as well as multiple homes, of subdivided. There is access to Hwy 521.
Unique opportunity to own a 3-bedroom, 2-bath home situated on 6.16 acres of land with commercial/business zoning. This versatile property offers endless possibilities — live where you work, develop for business use, or hold as an investment. The home features spacious living areas, a large kitchen, and beautiful acreage offering privacy and expansion potential. Conveniently located with excellent visibility and easy access to major highways and local amenities. Ideal for entrepreneurs, investors, or those seeking a property with both residential and commercial flexibility. HOME IS BEING SOLD AS IS AND WHERE IS
Location, Location! Minutes from MUSC (Medical University of South Carolina) 2 Professional buildings on one property! Lease one out and occupy the other. Building 1 (1201 Colonial Commons Ct) is currently set up as a medical office with about 14 rooms, separate file room, reception area, waiting room. Wired for X-ray room, upper level work area. Building 2 (1203 Colonial Commons Ct) offers three curtained areas, reception area, waiting room area, file room, large open space area, and work stations on upper level. Please see zoning chart from the City of Lancaster attached. New flooring and new roof installed in Building 1. Per the City of Lancaster, this is zoned "PO" Professional Office. Please reference zoning docs attached.
Investors take note. One parcel with 4 buildings. Zoning is GB. 6 potential rental opportunities. 2 are currently rented. Endless possibilities with the variety of businesses that can be in the buildings. Currently 2 auto repair businesses are being rented to. Each has bathroom and roll up doors. One was previously a salon one was an office and a previous restaurant. This large parcel also includes a vacant area perfect for a parking lot or another business. There is a fire wall separating the store and the property that is up for sale. The store is NOT part of the sale. Total property is 1.6 acres on one tax map number. Sold as is.
Versatile combined 3.96-acre property featuring a 1916 home, ideally located just on Highway 521 in a prime, fast-growing area. Ideal for commercial development, mixed-use projects, residential use, or an event venue potential. Close to shopping, dining, schools, and all conveniences, this property offers tremendous potential for investors or entrepreneurs looking to capitalize on one of the region’s most sought-after locations. Combined acreage of 3.96. Currently zoned Low Density Residential. As of 9/26/25 Lancaster County UDO future land use map has it labeled as Growth area meaning Commercial Zoning would be allowed w/Design and Environmental guidelines. County Water available on 521-Contact Lancaster County Water and Sewer as tap fee is required. The Lancaster County 9 month moratorium states it can be subdivided up to 3 parcels. Located in the Southern Panhandle Small Area Plan -https://www.lancastercountysc.gov/251/Southern-Panhandle-Small-Area-Plan Highway 521 is proposed to be widened. Mobile home on property is not habitable. Septic and repair fields on are adjoining property owned by family members, there is no written agreement. There is a buried fuel tank on the property; seller makes no representation as to its condition.
Buy 2 commercial building for 1 price!!! Do not miss this good chance!! Retail commercial property for sale. Rare to find this business property in this growing area. 1313 Hwy 9 Bypass property 2175 Sq included. (Currently leased for Antic store). This property runs dry cleaner plant all equipment and inventory will be conveyed. You can have a chance to be an owner of property and business owner.
Exceptional opportunity to acquire a thriving child development center—a unique find in this area—featuring two freestanding buildings on a level lot with an outdoor playground. The property includes a +/- 5,000 SF daycare/preschool facility thoughtfully designed with classrooms and administrative space, as well as a separate +/- 5,000 SF gymnasium building that supports youth programs and activities. Licensed for a capacity of up to 225 students, this center is well established and positioned for continued success. Offered as a business sale with all contents included, the new owner can seamlessly continue operations, making this a turnkey option for childcare and early education services with strong growth potential. Business purchase with lease option also available-contact listing agent for details!
Andrea Conner, License #298336, Xome Inc., License #C24582, [email protected], 844-400-9663, 750 State Highway 121 Bypass, Suite 100, Lewisville, TX 75067

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Lancaster is located in South Carolina. Lancaster, South Carolina has a population of 8,489. Lancaster is less family-centric than the surrounding county with 14.14% of the households containing married families with children. The county average for households married with children is 28.03%.
The median household income in Lancaster, South Carolina is $29,738. The median household income for the surrounding county is $67,407 compared to the national median of $69,021. The median age of people living in Lancaster is 37 years.
The average high temperature in July is 90.6 degrees, with an average low temperature in January of 29.3 degrees. The average rainfall is approximately 44 inches per year, with 1.7 inches of snow per year.